In conclusion, it can be suggested that carvacrol
may have an anticancerogenic effect and it could
be used as a drug substance to cure cancer.
However, more research concerning the possible utility of carvacrol in cancer treatment is war-
ranted.
(Introduction Carvacrol is a phenolic compound present in the essential oil fraction of oreganum and thyme. It has been shown to exhibit antibacterial and anti- fungal activity and its primary site of toxicity is the membrane, causing damage and collapse of the integrity of this membrane and leakage of vital intracellular constituents (Periago and Moezelaar 2001).)
Carvacrol, the predominant monoterpene in many essential oils of Labitae including Origanum, Satureja, Thymbra, Thymus, and Corydothymus has substantial antibacterial, antifungal, antihelmintic, insecticial, analgesic and antioxidant activities. Approximately 75% of lung cancer is non-small cell carcinoma (NSCLC) which comprises several histologic types squamous cell, adenocarcinoma and large cell carcinoma. It was reported that the portion of lung tumors diagnosed as denocarcinoma has increased. Thus a human non-small cell lung cancer (NSCLC) cell line, A549 was chosen for this study.To investigate the effects of carvacrol on cell morphology, apoptosis and total protein amount, the cells incubated with various concentration of carvacrol in DMSO for 24 h. In carvacrol applied A549 cell line, increase in dose of carvacrol caused a decrease in cell number, degeneration of cell morphology and a decrease in total protein amount. To characterize carvacrol induced changes in cell morphology, cells were examined by light microscopy. Cells were treated with carvacrol were seen to have detached from the disk, with cell rounding, cytoplasmic blebbing and irregularity in shape. The data demonstrate that carvacrol is very potent inhibitor of cell growth in A549 cell line.
Link to Full Text PDF
Subscribe by email for free for a limited time to see more scientific studies on essential oils?
http://essentialoilskeptic.com
(Introduction Carvacrol is a phenolic compound present in the essential oil fraction of oreganum and thyme. It has been shown to exhibit antibacterial and anti- fungal activity and its primary site of toxicity is the membrane, causing damage and collapse of the integrity of this membrane and leakage of vital intracellular constituents (Periago and Moezelaar 2001).)
Cytotechnology. 2003 Nov;43(1-3):149-54. doi: 10.1023/B: CYTO.0000039917.60348.45.
Effects of Carvacrol on a Human Non-Small Cell Lung Cancer (NSCLC) Cell Line, A549.
Abstract
- PMID:
- 19003220
- [PubMed]
- PMCID:
- PMC3449592
Subscribe by email for free for a limited time to see more scientific studies on essential oils?
http://essentialoilskeptic.com