Attenuation of oxidative stress in streptozotocin-induced diabetic rats by Eucalyptus globulus.
Abstract
In
traditional medicine, Eucalyptus globulus (eucalyptus) was used for the
treatment of diabetes mellitus. Hyperglycemia in diabetes has been
associated with increased formation of reactive oxygen species (ROS) and
oxidative damage to tissue compounds. The aim of this study was to
evaluate the effects of eucalyptus in the diet (20 g/Kg) and drinking
water (2.5 g/L) on lipid peroxidation, protein oxidation and antioxidant
power in plasma and liver homogenate, as well as glycated-Hb (HbA(1C))
of blood in streptozotocin-induced diabetic rats for a period of 4
weeks. Diabetes induced in rats by a single intraperitoneal injection of
streptozotocin (STZ, 65 mg/Kg). At the end of the treatment period, the
level of plasma glucose, plasma and liver malondialdehyde (MDA, the
main product of lipid peroxidation), protein carbonyl (PC, one of the
protein oxidation products) and HbA(1C) increased and ferric reducing
antioxidant power (FRAP) decreased in diabetic rats compared to normal
rats. Eucalyptus administration for 4 weeks caused a significant
decrease in the plasma glucose levels, plasma and liver MDA, PC and
HbA(1C), also a concomitant increase in the levels of FRAP in diabetic
treated rats. In conclusion, the present study showed that eucalyptus
posses antioxidant activities. Eucalyptus probably restores antioxidant
power, due to the improved hyperglycemia in streptozotocin-induced
diabetic rats.
KEYWORDS:
Diabetes mellitus; Eucalyptus globulus; Ferric reducing antioxidant power; Glycated-Hb; Malondialdehyde; Protein Carbonyl- PMID:
- 23105871
- [PubMed]
- PMCID:
- PMC3453050
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