About this blog

After seeing news articles say there was NO EVIDENCE that essential oils work for Ebola and hearing that the FDA has not approved any oils for any sort of disease, I decided to see what was out there and expose the essential oil industry. Instead, I found a mountain of peer reviewed studies for all kinds of serious diseases saying how well they work, even on Ebola! So, I decided to set up this blog to post a few studies a week to expose the real frauds and show the world what NO EVIDENCE looks like.
If you find value in my service, please donate to the blog since there is a cost to search and post these articles. I have waded through hundreds, if not thousands of difficult peer-reviewed articles to bring you those related to essential oils and ailments. I hope you find what you are looking for. I wish you great health, wealth and happiness!

(TIP: When looking for an article look in the Archive for titles but also use the Search Box because some articles may delay with say cancer in the title but also mention another disease so they may have tags that allow you to find them in the Search Box.)

Breast Cancer and Boswellic Acid


Volume 2, Issue 1, January–March 2012, Pages 31–37
"Here, we report boswellic acid as a potent anticancer agent that acts against multiple intracellular targets that affect angiogenesis (VEGF), inflammation (TNF-α, IL-12), apoptosis (caspase-3 & -9) and antioxidant (SOD & CAT) based anticarcinogenic mechanisms."

Antiangiogenic and cytotoxic activity of boswellic acid on breast cancer MCF-7 cells

  • Genome Research Laboratory, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, MB Road, New Delhi 110017, India

Abstract

Boswellic acid possesses anticancer activity, however, its underlying mechanism(s) remain unexplored. Here, we report boswellic acid as a potent anticancer agent that acts against multiple intracellular targets that affect angiogenesis (VEGF), inflammation (TNF-α, IL-12), apoptosis (caspase-3 & -9) and antioxidant (SOD & CAT) based anticarcinogenic mechanisms. It inhibits MCF-7 cell proliferation and potentiates the cell death induced by VEGF antibody. A dose-dependent decrease in the levels of VEGF and TNF-α and significant increase in caspases-3 and -9 activities in MCF-7 cells were observed. To conclude, the results of the present study suggest that boswellic acts via multiple albeit specific molecular targets to elicit anticarcinogenic activity.

Keywords

  • Boswellic acid MCF-7
  • Vascular endothelial growth factor
  • Apoptosis
  • Angiogenesis
Corresponding author.
 
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